The complement system, one of the ancient systems of the immune system may be affecting the severity of COVID disease, with regards to a study done by researchers from the Columbia University Irving Medical Center.

According to extensive findings, it was discovered that people with age-related macular degeneration -- a disorder caused by overactive complement –are more susceptible to developing severe complications and dying from COVID.

The link with complement suggests that current drugs that inhibit the complement system could help treat patients with severe disease.

They also found evidence clotting activity is possibly linked to COVID severity and that mutations in certain complement and coagulation
genes are associated with the hospitalization of COVID patients.

The study was published on Aug. 3 in Nature Medicine.